CoreAge Rx: Time Out ↗
Current advertised formula and starting price. Commercial claims; no completed purchase or independent product testing.
Checked 2026-09-26The publication / Sources
Every source has
its place.
Provider pages describe an offer. Studies describe an experiment. Neither replaces an individual clinical assessment.
Checked September 26, 2026. We used TinyFish for current discovery and page retrieval, with rendered-page checks where purchase details needed clarification. Historical papers are identified by their original publication year.
Provider
Alloy: M4 Face Cream Rx ↗
Current product and supply-price details, checked with TinyFish and a rendered browser page. Marketing claims are attributed.
Checked 2026-09-26Musely: The Aging Repair Cream ↗
Rendered page confirms two-month auto-refill and a separate one-time price. Outcomes described by Musely as self-reported.
Checked 2026-09-26Midi: Estriol+ Face Cream ↗
Current supply price and rendered formula description. Exact prescribed strengths require confirmation.
Checked 2026-09-26Midi: Custom Rx Express ↗
Supply presentation and care pathway; published review-time estimate differs from the product page.
Checked 2026-09-26Regulatory
FDA: Menopause ↗
States that no estriol-containing drugs are FDA-approved. General hormone information is not a product-specific risk estimate.
Checked 2026-09-26FDA: Understanding the risks of compounded drugs ↗
Explains that compounded drugs are not FDA-approved and distinguishes their premarket oversight.
Checked 2026-09-26FDA: February 2026 hormone-therapy labeling changes ↗
February 12, 2026 announcement concerning six specified approved products. It is not approval of estriol face creams.
Checked 2026-09-26Clinical guidance
AAD: Skin care during menopause ↗
Dermatology guidance about skin changes, moisturization, sun protection and assessment. Not a recommendation for a particular estriol product.
Checked 2026-09-26Research
1994 pilot study: topical estrogen and skin ageing ↗
Abstract reviewed. Eighteen participants, six months; preliminary findings, not a trial of the current brands.
Checked 2026-09-261996 study: treatment of skin aging with topical estrogens ↗
Abstract reviewed. Fifty-nine participants, six months; does not establish results for every compounded formula.
Checked 2026-09-261993 report: systemic effects of topical estrogens ↗
Abstract reviewed. Seventeen women over three months; limited measurements cannot exclude all systemic exposure or long-term outcomes.
Checked 2026-09-26Alloy-sponsored clinical report, June 2024 ↗
Public 34-page report reviewed: short, single-site controlled study. Commercial sponsor is disclosed; not a comparison of all listed brands.
Checked 2026-09-262026 JAAD systematic review: bibliographic record ↗
Record only. No abstract available and full text not obtained; no detailed conclusions attributed to this review.
Checked 2026-09-26